Juläine™ Biostimulator
A next-generation PLLA collagen activator, designed to naturally rebuild your skin's structural foundations for progressive, long-lasting rejuvenation.
"Beauty isn't created. It's revealed."
Book a Consultation"I've had several appointments with Dr Etienne Raffner now. He's a great doctor as he always listens to my concerns and gives plenty of advice and encouragement."
— Google Review"Dr Raffner is an incredibly skilled and knowledgeable surgeon. His attention to detail and care for his patients is second to none."
— Google Review"Absolutely fantastic experience with Dr Raffner. He made me feel completely at ease and the results are beautiful and natural."
— Google Review"Dr Etienne is so professional and reassuring. He took the time to explain everything in detail. I couldn't be happier with the results."
— Google Review"Outstanding care from Dr Raffner. You can really tell he has a surgical background — so precise and thorough. Highly recommend."
— Google Review"The most natural-looking results I've ever had. Dr Raffner's medical expertise really shows. He has a wonderful, calming manner."
— Google Review"I felt completely confident in Dr Raffner's hands. His knowledge as a maxillofacial surgeon makes such a difference to the quality of results."
— Google Review"I've had several appointments with Dr Etienne Raffner now. He's a great doctor as he always listens to my concerns and gives plenty of advice and encouragement."
— Google Review"Dr Raffner is an incredibly skilled and knowledgeable surgeon. His attention to detail and care for his patients is second to none."
— Google Review"Absolutely fantastic experience with Dr Raffner. He made me feel completely at ease and the results are beautiful and natural."
— Google Review"Dr Etienne is so professional and reassuring. He took the time to explain everything in detail. I couldn't be happier with the results."
— Google Review"Outstanding care from Dr Raffner. You can really tell he has a surgical background — so precise and thorough. Highly recommend."
— Google Review"The most natural-looking results I've ever had. Dr Raffner's medical expertise really shows. He has a wonderful, calming manner."
— Google Review"I felt completely confident in Dr Raffner's hands. His knowledge as a maxillofacial surgeon makes such a difference to the quality of results."
— Google ReviewWhat Is Juläine™?
Juläine™ is a cutting-edge PLLA (Poly-L-Lactic Acid) injectable biostimulator, developed by Nordberg Medical — a Swedish biotech company specialising in regenerative biomaterial science. Unlike traditional dermal fillers that add immediate volume, Juläine works by stimulating your skin's own fibroblasts to produce new collagen — specifically collagen types I and III, the two key structural proteins that determine skin strength, elasticity and resilience.
From the age of 25, our natural collagen production declines by 1–2% per year, leading to loss of elasticity and volume, fine lines, and a progressively tired, sagging appearance. Juläine addresses this at the source — triggering the body's own regenerative response through a scientifically advanced, low-inflammatory pathway.
What sets Juläine apart is its patented LASYNPRO™ microsphere technology — highly uniform, spherical PLLA microspheres that integrate smoothly into tissue and release lactic acid gradually. This controlled degradation activates fibroblasts and M2 macrophage polarization, stimulating collagen synthesis without triggering significant inflammation, for a more comfortable experience and naturally progressive results.
At Oving Medical Clinic, Dr Etienne Raffner administers Juläine as part of a personalised skin rejuvenation programme. His background as a Specialist Grade Maxillofacial & Oral Surgeon ensures an unparalleled level of anatomical precision and injection technique.
The Science Behind Collagen Loss
Key Benefits of Juläine™
How Does Juläine™ Work?
Injection of PLLA microspheres
Juläine is injected into the dermal layer using a fine 26G needle or 25G cannula. The ultra-light LASYNPRO™ microspheres integrate smoothly into surrounding tissue with minimal discomfort.
Gradual lactic acid release
As the PLLA microspheres slowly biodegrade, they release lactic acid — a recognised multifunctional signalling molecule that activates fibroblasts through a low-inflammatory signalling pathway.
Collagen synthesis activated
Fibroblast activation and M2 macrophage polarization promote the natural production of collagen types I and III — restoring skin strength, elasticity and structural integrity progressively over weeks to months.
Progressive, long-lasting results
Visible improvements appear at 2–3 months and continue to develop over 6–12 months. Results typically last over one year, with maintenance sessions recommended every 12–18 months.
Clinical Results
Juläine™ delivers progressive, natural-looking improvements over 2–7 months. Results are from clinical study data (Urdiales et al. 2025, Journal of Cosmetic Dermatology). Individual results may vary.
Results at 2 months after 2nd session — nasolabial fold
Results at 7 months after 3rd session — nasolabial fold
*AI-generated illustrative images. Individual results may vary.
Start your collagen renewal journey
Dr Raffner will assess your skin in detail and recommend whether Juläine — alone or as part of a combination programme — is the right approach for your goals.
Book a ConsultationPricing
Final pricing confirmed at consultation based on your individual treatment plan.
View full price listFrequently Asked Questions
Related Treatments
Ready to reveal your skin's natural potential?
Book a consultation with Dr Raffner to find out if Juläine is right for you.
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